ECG markers of local but not global increase in dispersion of ventricular repolarization (simulation study)
NV Arteyeva, JE Azarov - Journal of Electrocardiology, 2020 - Elsevier
Background An increase in local dispersion of repolarization (DOR) may contribute more to
arrhythmogenesis as compared to changes of global DOR. The aim of this simulation study
was to find ECG markers of local increase in DOR in conditions where global DOR remains
normal. Methods In the framework of van Oosterom and Oostendorp ECGSIM model, the
local DOR was increased in 10 different ventricular locations by (1) action potential duration
(APD) shortening/lengthening both on epi-and endocardium,(2) epicardial APD shortening …
arrhythmogenesis as compared to changes of global DOR. The aim of this simulation study
was to find ECG markers of local increase in DOR in conditions where global DOR remains
normal. Methods In the framework of van Oosterom and Oostendorp ECGSIM model, the
local DOR was increased in 10 different ventricular locations by (1) action potential duration
(APD) shortening/lengthening both on epi-and endocardium,(2) epicardial APD shortening …
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